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Cell Death Differ (2020) 27(3):103651

This circumstance leads to the potential for substantial expansion of total-body urate stores over time, even with a relatively moderate increase in uric production or decrease in uric acid elimination, as schematized in Figure 1 - 3B

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Even Renue seems a little confused about this one, as its site suggests letting the powder dissolve under your tongue or mixing it into a beverage, which would result in a massive difference in efficacy